miR-101 microRNA precursor is a small non-coding RNA that regulates gene expression. Expression of miR-101 has been validated in both human (MI0000103, MI0000739) and mouse (MI0000148). This microRNA appears to be specific to the vertebrates and has now been predicted or confirmed in a wide range of vertebrate species (MIPF0000046). The precursor microRNA is a stem-loop structure of about 70 nucleotides in length that is processed by the Dicer enzyme to form the 21-24 nucleotide mature microRNA. In this case the mature sequence is excised from the 3' arm of the hairpin.

Survival analysis shows that hsa-miR-101 is associated with survival in multiple breast cancer datasets.

References

Further reading

  • He XP, Shao Y, Li XL, Xu W, Chen GS, Sun HH, Xu HC, Xu X, Tang D, Zheng XF, Xue YP, Huang GC, Sun WH (November 2012). "Downregulation of miR-101 in gastric cancer correlates with cyclooxygenase-2 overexpression and tumor growth". The FEBS Journal. 279 (22): 4201–12. doi:10.1111/febs.12013. PMID 23013439. S2CID 205132426.

External links

  • Page for mir-101 microRNA precursor family at Rfam
  • miRBase family MIPF0000046

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MicroRNA (miRNA) biogenesis and function. Precursor molecules termed

Mir 17 microRNA precursor family Alchetron, the free social encyclopedia

microRNA Precursor & Knockdown Constructs

(a) From a list of >200 genes that were predicted to be miR101b