São Tomé (Portuguese for Saint Thomas) may refer to the following places:
- Brazil:
- São Tomé, Paraná
- São Tomé, Rio Grande do Norte
- São Thomé das Letras, a touristic town in Minas Gerais
- India:
- Chennai, known as São Tomé when under Portuguese control
- Portugal:
- São Tomé de Abação, a parish in the municipality of Guimarães
- São Tomé and Príncipe:
- São Tomé, capital city of São Tomé and Príncipe
- São Tomé Island, an island in São Tomé and Príncipe
